trichloro ethylene
Physical and chemical properties
Density: 1.463g/cm3
Melting point: -86℃
Boiling point: 87℃
Refractive index: 1.467 (20℃)
Saturated vapor pressure: 7.87kPa (20℃) [3]
Critical temperature: 299℃ [3]
Ignition temperature: 420℃ [3]
Upper explosion limit (V/V) : 90.0% [3]
Lower explosive limit (V/V) : 12.5% [3]
Appearance: Colorless transparent liquid
Solubility: insoluble in water, soluble in ethanol, ether, can be miscible in most organic solvents [2]
Molecular structure data
Molar refractive index: 25.76 [3]
Molar volume (cm3/mol) : 89.1 [3]
Isotonic specific volume (90.2K) : 210.4 [3]
Surface tension (dyne/cm) : 31.0 [3]
Polarizability (10-24cm3) : 10.21 [2]
Computational chemical data
Reference value of hydrophobic parameter calculation (XlogP) : 2.6 [3]
Number of hydrogen bond donors: 0 [3]
Number of hydrogen bond receptors: 0 [3]
Number of rotatable bonds: 0 [3]
Number of tautomers: None
Topological molecular polar Surface area (TPSA) : 0 [3]
Number of heavy atoms: 5 [3]
Surface charge: 0 [3]
Complexity: 42.9 [3]
Number of isotope atoms: 0 [3]
Determine the number of atomic constitutive centers: 0 [3]
Number of uncertain atomic orthotic centers: 0 [3]
Determine the number of chemical bond constitutive centers: 0 [3]
Number of uncertain bond constitutive centers: 0 [3]
Number of covalent bond units: 1 [2]
Toxicological data
1. Acute toxicity
LD50:2402mg/kg (Mouse transoral)
LC50:137752mg/m3 (rat inhalation, 1h); 45292mg/m3 (Mouse inhalation, 4h)
2. Stimulation
Rabbit transdermal: 500mg (24h), severe stimulation.
Rabbit meridian eye: 20mg (24h), moderate irritation.
3. Subacute and chronic toxicity
LC value at 6 months exposure: 1.08g/m3 in rats and rabbits
4. Mutagenicity
DNA inhibition: human lymphocyte 5mg/L.
Sister chromatid exchange: human lymphocyte 178mg/L.
Extra-procedural DNA synthesis: Human lung 100mg/L.
DNA Inhibition: Human Lymphocyte 5ml/L.
Sister chromatid exchange: human lymphocyte 178mg/L.
5. Teratogenicity
The lowest toxic dose (TCLo) of 1800ppm (24h) was inhaled from 1 to 20 days after pregnancy, resulting in malformation of musculoskeletal system and genitourinary system.
The lowest toxic dose (TCLo) of 150ppm (24h) was inhaled in male and female mice from 4 weeks before mating to 3 weeks after pregnancy, causing developmental malformations of the central nervous system.
The lowest toxic dose (TDLo) of 156mg/kg was given orally to rats in multiple generations, resulting in developmental malformations of genitourinary system.
The lowest toxic dose (TDLo) of 700mg/kg was given orally to mice in multiple generations, resulting in developmental malformations of hepatobiliary duct system and genitourinary system.
The lowest dose (TDLo) of 1010mg/kg was detected in rats 6 to 15 days after pregnancy, resulting in deformities of eyes and ears.
Immunological and reticuloendothelial dysplasia in mice given the lowest toxic dose (TDLo) orally over multiple generations.
6. Carcinogenicity
IARC carcinogenicity Review: G2A, a possible human carcinogen.
7. Others
The lowest inhalation concentration (TCLo) in rats: 1800 PPM (24h) (1~20d) caused musculoskeletal dysplasia and other developmental abnormalities.
Minimum toxic concentration (TCLo) inhaled in mice: 100ppm (7h) (5d, male), abnormal spermatogenesis. [2]
Ecological data
1. Ecological toxicity
LC50:44.7mg/L (96h) (Bluegill sunfish, static); 40.7~66.8mg/L (96h) (minnows); 20mg/L (96